The role of The amygdala in emoTional memories: a mulTidisciplinary approach
نویسنده
چکیده
German version __________________________________________________ 9 1. The amygdala_________________________________________________________ 11 1.1. General anatomy and connectivity................................................................................... 12 1.1.1. Anatomy........................................................................................................................................ 12 1.1.2. Connectivity .................................................................................................................................. 15 1.1.2.1. Sensory inputs...................................................................................................................... 15 1.1.2.2. Intramygdaloid connections................................................................................................. 15 1.1.2.3. Efferent connections ............................................................................................................ 16 1.2. The function of the amygdala in the brain ...................................................................... 17 1.2.1. Responses to emotionally salient stimuli ...................................................................................... 17 1.2.2. Attention........................................................................................................................................ 18 1.2.3. Modulation of memory processes ................................................................................................. 18 1.2.4. Fear conditioning .......................................................................................................................... 19 1.2.5. Anxiety.......................................................................................................................................... 21 1.2.6. Regulation of hormonal and autonomic responses........................................................................ 21 1.2.7. Socio-emotional behaviour ........................................................................................................... 22 1.2.8. Implications for pathological states............................................................................................... 23 2. Aversive memories, the amygdala and PSA-NCAM _________________________ 25 2.1. Structure and function of neural cell adhesion molecules.............................................. 26 2.1.1. NCAM........................................................................................................................................... 28 2.1.2. PSA-NCAM .................................................................................................................................. 30 2.1.3. Models of neural cell adhesion molecule functioning................................................................... 34 2.2. NCAM and PSA-NCAM in activity-induced synaptic plasticity ................................... 35 2.2.1. Role of NCAM/PSA-NCAM in dentate gyrus synaptic plasticity ................................................ 37 2.2.2. Role of NCAM/PSA-NCAM in CA3 synaptic plasticity .............................................................. 37 2.2.3. Role of NCAM/PSA-NCAM in CA1 synaptic plasticity .............................................................. 39
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